In 1832, possibly after the mediation of Ludwig Thiersch, he went to Munich, where he attended the “Panhellenion”, the Greek pedagogical school founded by Ludwig I for the orphans of the fighters of the Revolution. Twelve years later, in 1844, he was accepted into the Munich Academy of Fine Arts. Supported by a scholarship of the local Greek community until 1855, he had the opportunity to travel around Europe. From 1848 to 1851 he lived in Greece, in order to study the land and the people that he was going to depict in his historical scenes. Prior to that, while still in Munich, he had become acquainted with the work of Peter von Hess, Carl von Heideck, Joseph Petzl, Karl Krazeisen and Joseph Stieler, a fact which serves to explain the shaping of his particular style within the spirit of classical romanticism, as well as his choice of painting themes from among the events of recent Greek history.
A pioneer of the Munich School, he focused systematically on the depiction of scenes from the liberation struggle and its well- or less-known protagonists, in accordance with the principles of the Academy. This type of theme was particularly popular and his works were reproduced as lithographs, circulated widely and imprinted in the collective conscience as authentic representations of modern Greek history. Yet another aspect of his artistic creation was the painting of portraits, in which Vryzakis emerges as a portrait master, fully owning his means of expression.